Cellular Targets

Electron micrograph of HIV-1(IIIB) chronically infected H9 cell. (courtesy of Dr. Jacquelline Muller, FDA, CBER).
Cellular Receptors
Immunoglobulin Superfamily
CD4
Chemokine (Seven-transmembrane) Receptor Superfamily
CXCR4 (also known as Fusin; LESTR; NPY3R)
CCR5 (also known as CKR-5; CMKRB5)
CCR3 (also known as CC-CKR-3; CKR-3; CMKBR3)
CCR2 (also known as CCR2b; CMKBR2)
CCR1 (also known as CKR1; CMKBR1)
CCR4 (also known as CKR-4)
CCR8 (also known as ChemR1; TER1; CMKBR8)
CCR9 (also known as D6)
CXCR2 (also known as IL-8RB)
STRL33 (also known as Bonzo; TYMSTR)
US28
V28 (also known as CMKBRL1; CX3CR1; GPR13)
gpr1 (also known as GPR1)
gpr15 (also known as BOB; GPR15)
Apj (also known as angiotensin-receptor-like; AGTRL1)
ChemR23
Miscellaneous Cell Surface Molecules
CD26
Heparan Sulfate Proteoglycans
Galactoceramides
Erythrocyte-expressed Glycolipids
Other Cell Surface Molecules
Intracellular Targets
Cellular Enzymes
N-myristoyltransferase
Glycosylation Enzymes
gp-160 Processing Enzymes
Ribonucleotide Reductase
Polyamine Biosynthesis
Cellular Transcription Factors
Sp1
NF-kB
Cytokines and Second Messengers
Tumor Necrosis Factor-a (TNF-a)
Interleukin 1a (IL-1a)
Interleukin 6 (IL-6)
Phospholipase C
Protein Kinase C
Intracellular Calcium
Cellular Accessory Molecules
Cyclophilins
MAP-Kinase (Mitogen Activated Protein Kinase)
ERK-Kinase (Extracellular Signal-Regulated Kinase)